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Screening Information Data Set (SIDs) for High Production Volume Chemicals

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Triethylene glycol butyl ether (Screening Information Data Set - SIDs)
    12-14-06, http://www.inchem.org/documents/sids/sids/eges.rev.pdf
    Summary: 143-22-6 23783-42-8 1559-34-8 Chemical Name Triethylene glycol butyl ether Tetraethylene glycol methyl ether Tetraethylene glycol butyl ether Structural Formula HO(CH2CH2O)nR n= 3 or 4; R=methyl or butyl Note: Both tetraethylene glycol methyl ether and tetraethylene glycol butyl ether are available as mixtures with other glycol ethers and some other compounds. Impurities include: Polyethylene glycol butyl ether (9004-77-7); Diethylene glycol butyl ether (112-34-5); Triethylene glycol (...

Naphthol, 2- (Screening Information Data Set - SIDs)
    12-14-06, http://www.inchem.org/documents/sids/sids/135193.pdf
    Summary: All other data have been checked and validated by UBA and BUA OECD SIDS 2-NAPHTHOL UNEP PUBLICATIONS 3 9. Date of Submission: 08. August 2002 10. Date of last Update: - 11. Comments: - OECD SIDS 2-NAPHTHOL UNEP PUBLICATIONS 4 SIDS INITIAL ASSESSMENT PROFILE CAS No. OECD SIDS 2-NAPHTHOL UNEP PUBLICATIONS 21 Chronic Toxicity Test Results Only one NOEC obtained in a long-term study is available.

Tribromophenol, 2,4,6- (Screening Information Data Set - SIDs)
    12-14-06, http://www.inchem.org/documents/sids/sids/118796.pdf
    Summary: According to the OECD test guidelines for combined repeated dose toxicity study with the reproduction/developmental toxicity screening test [OECD TG 422], SD (Crj: CD) rats were administrated by gavage at doses of 0 (vehicle; corn oil), 100, 300, and 1,000 mg/kg/day (12 animal/dose/sex). OECD SIDS 2,4,6-TRIBROMOPHENOL UNEP PUBLICATIONS 17 Studies in Animals Effects on Fertility Oral Study: The combined repeated dose toxicity study with the reproduction/developmental toxicity screening test [...

Triphenyl phosphate (Screening Information Data Set - SIDs)
    12-14-06, http://www.inchem.org/documents/sids/sids/115866.pdf
    Summary: Although no reliable data on accumulation of triphenyl phosphate can be derived from this study, OECD SIDS TRIPHENYL PHOSPHATE UNEP PUBLICATIONS 11 BCFs for Lemna minor and Typha sp. OECD SIDS TRIPHENYL PHOSPHATE UNEP PUBLICATIONS 15 3.1.3 Irritation Skin Irritation Studies in Animals The skin irritation potential of triphenyl phosphate was determined in a study according to international standards (Bayer AG, 1990; OECD 404).

Thiodiglycol (Screening Information Data Set - SIDs)
    12-14-06, http://www.inchem.org/documents/sids/sids/111488.pdf
    Summary: OECD SIDS THIODIGLYCOL UNEP PUBLICATIONS 5 The aquatic effects data base meets the requirements of the SIDS package. OECD SIDS THIODIGLYCOL UNEP PUBLICATIONS 11 Table 2: Acute toxicity of thiodiglycol in experimental animals Route Species a LD50 Reliability/Remarks Reference Oral Rat (male, female; Sprague-Dawley; 8 dose levels, 2 animals/dose) Acute approximate lethal dose: > 9900 mg/kg bw 1/ slight lethargy of the male rat at 9900 mg/kg bw; no toxic effects in the female rats. 3.1.5 ...

Dimethylmalonate (Screening Information Data Set - SIDs)
    12-14-06, http://www.inchem.org/documents/sids/sids/malonates.pdf
    Summary: OECD SIDS MALONIC ACID DIESTERS UNEP PUBLICATIONS 5 For DEM only limited literature data are available. OECD SIDS MALONIC ACID DIESTERS UNEP PUBLICATIONS 6 Acute toxicity data for 3 trophic levels of the aquatic environment are available for both substances. OECD SIDS MALONIC ACID DIESTERS UNEP PUBLICATIONS 22 Conclusion DMM did not reveal any skin sensitizing effect in a Bühler test according to OECD TG 406 and GLP.

Diethylmalonate (Screening Information Data Set - SIDs)
    12-14-06, http://www.inchem.org/documents/sids/sids/malonates.pdf
    Summary: OECD SIDS MALONIC ACID DIESTERS UNEP PUBLICATIONS 5 For DEM only limited literature data are available. OECD SIDS MALONIC ACID DIESTERS UNEP PUBLICATIONS 6 Acute toxicity data for 3 trophic levels of the aquatic environment are available for both substances. OECD SIDS MALONIC ACID DIESTERS UNEP PUBLICATIONS 22 Conclusion DMM did not reveal any skin sensitizing effect in a Bühler test according to OECD TG 406 and GLP.

Diphenyl carbonate (Screening Information Data Set - SIDs)
    12-14-06, http://www.inchem.org/documents/sids/sids/102090.pdf
    Summary: The exhausts from manufacturing and processing of diphenyl carbonate are connected to absorbing units, thermal exhaust OECD SIDS DIPHENYL CARBONATE UNEP PUBLICATIONS 6 purification plants and air washing units, thus virtually no emissions of diphenyl carbonate occurred into the atmosphere. OECD SIDS DIPHENYL CARBONATE UNEP PUBLICATIONS 18 In a supplementary study doses of 2 to 200 mg/kg bw/day diphenyl carbonate were given to female rats (10/dose) over a similar period as in the ...

2-furanmethanol,tetrahydro (Screening Information Data Set - SIDs)
    12-14-06, http://www.inchem.org/documents/sids/sids/97994.pdf
    Summary: At 600 mg/kg bw/day, animals showed decreased body weight gain in males, reduced food consumption in males and females, and decreased urinary pH in males. In the repeated dermal toxicity study for 13 weeks in rats, the NOAELs were considered to be 100 mg/kg bw/day in males and 300 mg/kg bw/day in females. In a 28-day repeated oral dose toxicity study in rats, behavioural changes were found in males at 600 mg/kg bw/day and females at 150 mg/kg bw/day.

Toluidine,o- (Screening Information Data Set - SIDs)
    12-14-06, http://www.inchem.org/documents/sids/sids/95534.pdf
    Summary: In in-vitro tests for chromosomal aberrations o-toluidine yielded positive results in several cell systems and did induce micronuclei in human lymphocytes in-vitro. As results from further testing would not affect the most stringent exposure control measures being already in place due to genotoxicity and carcinogenicity of o-toluidine, no further tests are warranted. The test design is comparable to the Zahn-Wellens-test (OECD TG 302 B). The test substance o-toluidine in a concentration of ...


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