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Screening Information Data Set (SIDs) for High Production Volume Chemicals

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10 documents displayed.

Di-(2-ethylhexyl)adipate (Screening Information Data Set - SIDs)
    12-13-05, http://www.inchem.org/documents/sids/sids/103231.pdf
    Summary: A developmental toxicity performed with DEHA in rats (animals treated orally via DEHA in feed on days 6-15 of gestation) demonstrated reduced maternal body weight gain at the highest dose (1080 mg/kg/d). A chronic daphnid study did show effects at OECD SIDS BIS(2-ETHYLHEXYL)ADIPATE UNEP PUBLICATIONS 4 concentrations slightly above the water solubility limit. OECD SIDS BIS(2-ETHYLHEXYL)ADIPATE UNEP PUBLICATIONS 13 3 HUMAN HEALTH HAZARDS 3.1 Effects on Human Health 3.1.1 Acute Toxicity The ...

Ethylbenzene (Screening Information Data Set - SIDs)
    12-13-05, http://www.inchem.org/documents/sids/sids/100414.pdf
    Summary: OECD SIDS ETHYLBENZENE UNEP PUBLICATIONS 3 7. Review Process Prior to the SIAM: 8. Quality check process: 9. Date of Submission: Deadline for circulation: February 1, 2002 Date of Circulation: February 1, 2002 10. Date of last Update: 11. Comments: Testing: No testing ( X ) Testing ( ) OECD SIDS ETHYLBENZENE UNEP PUBLICATIONS 4 SIDS INITIAL ASSESSMENT PROFILE CAS No. 2.3 Human Exposure OECD SIDS ETHYLBENZENE UNEP PUBLICATIONS 16 2.3.1 Occupational Exposure U.S. ethylbenzene producers recently...

5-Ethylene-2-norbornene (Screening Information Data Set - SIDs)
    06-29-06, http://www.inchem.org/documents/sids/sids/16219753.pdf
    Summary: Analytical results for actual EDPM test materials showed that residual ENB concentration was less than 5 mg ENB/kg test material. Also, the dominant lethal study described above produced no effect on the testes of rats exposed to ENB concentrations up to 254 ppm for 5 days (Neeper-Bradley and Ballantyne, 1996) OECD SIDS 5-ETHYLIDENE-2-NORBORNENE UNEP PUBLICATIONS 14 An OECD reproductive/developmental toxicity screening test was conducted in Sprague-Dawley rats at doses of 0, 4, 20, and 100 mg...

Ethylene (Screening Information Data Set - SIDs)
    12-13-05, http://www.inchem.org/documents/sids/sids/74851.pdf
    Summary: About 5 - 10 % of ethylene inhaled by rats has been reported to be converted to ethylene oxide, depending upon the concentration of ethylene in the inhaled air. The oxidation of ethylene to ethylene oxide and subsequent alkylation of DNA and proteins identifies a possible mechanism of potential toxic effects of ethylene in humans. This ethylene is not due to emission of ethylene from ethylene production, but rather to incomplete burning of coal and petrol products.

Ethanol,2-(2-(2-methoxyethoxy)ethoxy- (Screening Information Data Set - SIDs)
    12-13-05, http://www.inchem.org/documents/sids/sids/112356.pdf
    Summary: Similarly, a 91-day repeated-dose dermal toxicity study in rats given 400, 1,200 or 4,000 mg TGME/kg/day showed severe testicular toxicity in 1/10 animals given 4,000 mg/kg/day and minimal decreases in developing germ cells in 1/10 rats given 1,200 mg/kg/day. Effects observed in offspring from rats treated with 1,250 mg/kg/day TGME or rabbits treated with 1,500 mg/kg/day TGME during gestation included skeletal variants and decreased body weight gain. In a gavage study, TGME was administered ...

Ethanol,2-(2-(2-ethoxyethoxy)ethoxy- (Screening Information Data Set - SIDs)
    12-13-05, http://www.inchem.org/documents/sids/sids/112505.pdf
    Summary: OECD SIDS 2-(2-(2-ETHOXYETHOXY)ETHOXY)-ETHANOL UNEP PUBLICATIONS 7 Table 3. Comparison of Existing Data Set for TGEE and TGME Environmental Testing TGEE TGME Biodegradability X X Acute Toxicity to Fish X X Acute Toxicity to Daphnids X X Toxicity to Algae X city to Bacteria X X Mammalian Testing Acute Oral Toxicity X X Acute Dermal Toxicity X X Acute Inhalation Toxicity X X Skin Sensitization Skin Irritation X X Repeated Dose Toxicity X X Reproductive Toxicity X Developmental Toxicity X X

Ethanol (Screening Information Data Set - SIDs)
    12-13-05, http://www.inchem.org/documents/sids/sids/64175.pdf
    Summary: Blood ethanol concentrations resulting from ethanol exposure by any other route are unlikely to produce reproductive or developmental effects. OECD SIDS ETHANOL UNEP PUBLICATIONS 5 Environment The available physicochemical data are adequate to describe the properties of ethanol. OECD SIDS ETHANOL UNEP PUBLICATIONS 13 2.3.7.2 Measured Environmental Concentrations There is no recent environmental data on ethanol concentrations.

Dodecyl benzene (Screening Information Data Set - SIDs)
    12-13-05, http://www.inchem.org/documents/sids/sids/LAB.pdf
    Summary: (C10-C13 LAB) 48 hr/ECC NOEC > 0.04 mg/L (C10-C13 LAB) 48 hr /OECD 202, part 1 NOEC > 0.1 mg/L (C10, C12, C14 LAB) OECD SIDS BENZENE, C10-C16 ALKYL DERIVATIVES UNEP PUBLICATIONS 5 CAS NO: 123-01-3 and 6742-54-7 SPECIES PROTOCOL RESULTS Mysidopsis bahia 96 hr/ASTM LC50 > water sol. Monsanto Report ABC-27561 Monsanto Report BD-84-277 Monsanto Report BD-84-315 Monsanto Report BT-65-2 Monsanto Report BT-65-3 Monsanto Report BT-65-4 Monsanto Report HL-84-290 Monsanto Report ML-80-58 Monsanto ...

1-dodecene (Screening Information Data Set - SIDs)
    12-13-05, http://www.inchem.org/documents/sids/sids/Aoalfaolefins.pdf
    Summary: The following SIDS Testing Plan was agreed: No testing ( ) Testing (x) Combined reproductive/developmental on 1-hexene, combined repeat dose/reproductive/developmental on 1-tetradecene and acute fish, daphnid and algae on 1- tetradecene. OECD SIDS ALFA OLEFINS UNEP PUBLICATIONS 7 SIDS INITIAL ASSESSMENT REPORT Due to the similarities of the C6-C14 alpha olefins, a category approach was utilized to determine the OECD test plan for these compounds. Results of three studies with these organisms ...

1-Dodecanol (Screening Information Data Set - SIDs)
    12-13-05, http://www.inchem.org/documents/sids/sids/112538.pdf
    Summary: 5.1.1.a Results of acute tests Test substance: 1-Dodecanol (purity not specified) Test species: Golden orf (Goldorfen) Test method (e.g. OECD, others): Test method and conditions not specified. 5.1.2 Results of long-term tests e.g., prolonged toxicity, early life-stage OECD SIDS 1-DODECANOL UNEP P bli i 20 (No information was found on long-term tests.) Test substance: Test species: Test method (e.g., OECD, others): . Test substance: Test species: Test method (e.g., OECD, others): GLP YES [ ] ...


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